Histopathology of endomyocardial biopsies (EMB) is the standard rejection surveillance for
heart transplants. However, ISHLT consensus criteria for interpreting biopsies are arbitrarily
defined. Gene expression offers an independent re‐evaluation of existing diagnostic
systems. We performed histologic and microarray analysis on 105 EMB from 45 heart
allograft recipients. Histologic lesions, diagnosis and transcripts were compared to one
another, time posttransplantation, indication for biopsy and left ventricular ejection fraction …